Genetic factors and manganese-induced neurotoxicity
نویسندگان
چکیده
منابع مشابه
Genetic factors and manganese-induced neurotoxicity
Manganese (Mn), is a trace metal required for normal physiological processes in humans. Mn levels are tightly regulated, as high levels of Mn result in accumulation in the brain and cause a neurological disease known as manganism. Manganism shares many similarities with Parkinson's disease (PD), both at the physiological level and the cellular level. Exposure to high Mn-containing environments ...
متن کاملManganese and Developmental Neurotoxicity.
Manganese (Mn) is an essential metal that plays a fundamental role for brain development and functioning. Environmental exposure to Mn may lead to accumulation in the basal ganglia and development of Parkinson-like disorders. The most recent research is focusing on early-life overexposure to Mn and the potential vulnerability of younger individuals to Mn toxicity also in regard to cognitive and...
متن کاملEpigenetics Involvement in Parkinson’s Disease and Manganese-Induced Neurotoxicity
Parkinson’s disease (PD) is a progressive neurological disorder of CNS and one of the most common neurodegenerative diseases. The exact mechanisms underlying PD has been unclear but it is believed that multiple factors are involved. Excessive exposure to manganese (Mn) can causes its accumulation in the human brain and subsequent neural damage and even development of PD-like movement disorder, ...
متن کاملPotential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity
Manganese is a vital nutrient and is maintained at an optimal level (2.5-5 mg/day) in human body. Chronic exposure to manganese is associated with neurotoxicity and correlated with the development of various neurological disorders such as Parkinson's disease. Oxidative stress mediated apoptotic cell death has been well established mechanism in manganese induced toxicity. Oxidative stress has a ...
متن کاملCurrent Challenges about Understanding of Manganese-Induced Neurotoxicity
Manganese (Mn) is found in three major biologically-relevant oxidation states Mn(II), Mn(III) and Mn(IV), and it is an essential trace metal that is involved for several pathway, in the normal cell function and metabolism. However, since XIX century, the Mn is well known as neuro (toxic) agent, during acute and chronic exposure for air, water or aliments containing either highor low-level conce...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2014
ISSN: 1664-8021
DOI: 10.3389/fgene.2014.00265